The “Principal Isoforms” section shows all the variants and highlights the principal isoforms. The isoforms are tagged with the flags PRINCIPAL, and ALTERNATIVE based on the range of protein features.
In the case of the APPRIS Database, the IDs and Names come from Ensembl transcript identifiers and transcript names, respectively. For the APPRIS WebServer, the IDS come from the sequence identifier of the FASTA sequence file.
A gene or transcript classification. Transcript types include protein coding, pseudogene, and long non-coding and short non-coding RNAs. For human, mouse and selected other species we incorporate the manual annotations from GENCODE. Where a gene o r transcript has been manually annotated, we use the manually assigned biotype. The full list of biotypes used by GENCODE are here.
If the transcript contains a variation whose alternative allele has a population frequency of at least 10% and is causing the loss or gain of a stop codon in a HapMap population, the variation and affected populations are listed.
If the transcript has a Consensus Coding Sequence, the CCDS ID will be listed.
APPRIS defines the principal variant by combining protein structural and functional information and information from the conservation of related species.